Clinical research with results

Our published research demonstrates measurable improvements in patient outcomes. We're sharing how evidence-based care can transform lives.

Featured Publications

Peer-reviewed studies

Clinically Meaningful Change in Psychiatry Patients of a Real-World Digital Mental Health Intervention: A Retrospective Analysis of Rula Health
New
Clinically Meaningful Change in Psychiatry Patients of a Real-World Digital Mental Health Intervention: A Retrospective Analysis of Rula Health
INQUIRY
, February 2026

Depression and anxiety are common, disabling conditions that often require sustained psychiatric care. This study evaluates the rate and timing of clinically meaningful improvement and remission in depression and anxiety among patients receiving psychiatry services through Rula Health.

Results: Moderate & severe psychiatry patients experience rapid symptom improvement, with 67-78% experiencing meaningful symptom improvement within only 12 weeks or less.
Real-World Symptom Trajectories in Adolescents With and Without Suicide Risk Receiving Care from Rula Health: Retrospective Study
Real-World Symptom Trajectories in Adolescents With and Without Suicide Risk Receiving Care from Rula Health: Retrospective Study
Journal of Medical Internet Research – Pediatrics and Parenting
, October 2025 

More than 5 million US adolescents experience mental or behavioral health conditions, yet two-thirds remain untreated, and suicide is the second leading cause of death. This study evaluates symptom improvements among adolescents with and without elevated suicide risk receiving care from Rula Health.

Results: Depression and anxiety scores decreased over visits, with average improvements exceeding minimal clinically important difference thresholds.
Predictors and Correlates of Depression and Anxiety Symptom Trajectories in a Large Digital Mental Health Provider: Retrospective Analysis of Data From Rula Health
Predictors and Correlates of Depression and Anxiety Symptom Trajectories in a Large Digital Mental Health Provider: Retrospective Analysis of Data From Rula Health
Journal of Medical Internet Research
, July 2025 

Patients across all acuity levels experience rapid symptom improvement at Rula, with depression and anxiety symptoms decreasing most substantially in the first 5 visits. This includes notably strong outcomes among historically underserved groups.

Results: Symptom reductions and patient improvement continued through the first 12 sessions of care. 

The Rula difference

A clinically validated, evidence-based care model

We provide compassionate, accessible care for patients, partners, employers, and more.

We’re always looking to partner with others who share our commitment to raising the standard of mental healthcare. 

Clinical excellence, compassionate care

Behind every published study is a team of clinicians committed to helping patients thrive. Their dedication drives our research and powers our outcomes.


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The 988 Suicide and Crisis Lifeline provides 24/7, confidential support with trained crisis counselors.

If you or a loved one is in emotional distress or a suicidal crisis, please call or text 988.